AIDS InfoNet Logo
This website is certified by Health On the Net Foundation. Click to verify.
This site complies with the HONcode standard for trustworthy health information:
verify here.

The Henry J. Kaiser Family Foundation
Site of the Week
November 2003

The Health Leader Award 2006
The Health Leader Award 2006

The HOPE Reward

Med411.com Medical Award

HealthAtoZ.com Featured Site Award

BuscaSalud.com

IBS Tales Hope Award

HealingWell.com Editor's Choice Award

Listed in Listed in Treasures of the Internet


AIDS InfoNet Logo.  The AIDS InfoNet - Reliable, Up-to-Date AIDS Treatment Information
International Association of Providers of AIDS Care
Revised May 29, 2014

Fact Sheet 467

Dolutegravir (Tivicay)


WHAT IS DOLUTEGRAVIR (TIVICAY)?
WHO SHOULD TAKE IT?
WHAT ABOUT DRUG RESISTANCE?
HOW IS DOLUTEGRAVIR TAKEN?
HOW DOES IT REACT WITH OTHER DRUGS?
THE BOTTOM LINE

 


WHAT IS DOLUTEGRAVIR?

Dolutegravir (formerly S/GSK1349572) is a drug used for antiviral therapy against HIV. It is manufactured by ViiV Healthcare.

Dolutegravir is the third “integrase inhibitor” drug. When HIV infects a cell, it combines its genetic code into the cell's own code. This is shown in fact sheet 400, step 5. Dolutegravir blocks this process. When dolutegravir blocks integration, HIV infects a cell but cannot make more copies of itself.

 


WHO SHOULD TAKE IT?

Dolutegravir was approved in 2013 as an antiviral drug against HIV. It is approved for adults and children age 12 years and older, who weigh at least 88 pounds (40 kilograms).

There are no absolute rules about when to start antiviral drugs. You and your health care provider should consider your CD4 cell count (see fact sheet 124) your viral load (see fact sheet 125) any symptoms you are having, and your attitude about taking HIV medications. Fact Sheet 404 has more information about guidelines for the use of antiviral medications.

 


WHAT ABOUT DRUG RESISTANCE?

The HIV virus is sloppy when it makes copies of its genetic code (RNA). Many new copies of HIV are mutations: they are slightly different from the original virus. Some mutations can continue to multiply even when you are taking an antiviral drug. When this happens, the drug will stop working. This is called "developing resistance" to the drug. See Fact Sheet 126 for more information on resistance.

Dolutegravir has shown activity against HIV that already has resistance to several other HIV medications, including some viruses with resistance to other HIV integrase inhibitors.

Resistance to dolutegravir is not yet well understood. Sometimes, if you develop resistance to one drug, you will also have resistance to other antiviral drugs. This is called "cross-resistance". Because dolutegravir is in a fairly new class of antiviral drugs, it seems to have no cross resistance with antiviral drugs in older classes. However, some cross-resistance is expected between raltegravir (Isentress, see fact sheet 465), elvitegravir (see fact sheet 466) and dolutegravir.

With combination therapy (taking more than one antiviral drug at the same time), HIV mutates much more slowly. Resistance takes longer to develop. It is very important to take antiviral medications according to instructions, on schedule, and not to skip or reduce doses.

 


HOW IS DOLUTEGRAVIR TAKEN?

Dolutegravir is taken as one 50 mg tablet once daily for people on HIV integrase inhibitor treatment for the first time. It is may be taken prescribed twice daily if you have already used raltegravir or elvitegravir and have viral resistance.

It can be taken with or without food or with regard to time of day. If you take certain antacids, calcium or iron supplements, there are can be timing requirements with dolutegravir. These can be overcome if dolutegravir and the supplement is taken with food.

 


WHAT ARE THE SIDE EFFECTS?

 

Dolutegravir is usually very well tolerated. The If side effects occur, the most the common side effects in people taking dolutegravir are diarrhea, nausea, and headache.

 

Among some individuals with hepatitis B or C virus infection, cases of liver inflammation were observed. Laboratory testing before starting therapy and monitoring for liver toxicity during therapy are recommended in patients with underlying liver disease. Reports from people using dolutegravir include rash. In rare cases, skin rash can be severe and life-threateninglife threatening. Contact your health care provider immediately if you develop a serious rash while taking dolutegravir.

 

 


HOW DOES IT REACT WITH OTHER DRUGS?

Dolutegravir has been studied to see if it interacts with other drugs. Rifampin, used to treat tuberculosis (see fact sheet 518), and the HIV medications efavirenz (see fact sheet 432), fosamprenavir/ritonavir (see fact sheet 448) and tipranavir/ritonavir (see fact sheet 449) decrease blood levels of dolutegravir. If dosed with and of these medications, dolutegravir should be dosed 50 mg twice daily. In these situations, dolutegravir is dosed twice daily. Dolutegravir should not be taken with the heart medication dofetilide.

Dolutegravir has not been studied with all medicines, over-the-counter drugs or vitamin or herbal supplements. Studies are underway. Be sure your doctor knows about all medications and supplements that you are taking.

 


THE BOTTOM LINE

Dolutegravir is the third drug in a new class, integrase inhibitors. It stops HIV from inserting its genetic code into an infected cell. This prevents the virus from making new copies of HIV. Dolutegravir helps control HIV, even when it is resistant to other medications.
 


 


Back to Fact Sheet Categories



New Mexico AIDS Education and Training Center The University of New Mexico Health Sciences Center International Association of Providers of AIDS Care

 

The AIDS InfoNet is a project of the New Mexico AIDS Education and Training Center at the University of New Mexico Health Sciences Center,
and the International Association of Providers of AIDS Care.
webmaster@aidsinfonet.org

 

United States National Library of Medicine

Partially funded by the National Library of Medicine



Search Our Site
Newest Fact Sheets
Print This Fact Sheet
You can print this fact sheet on a single page in Microsoft Word (.doc) format or Adobe Acrobat (.pdf) format. Click on the links below to open the document in your browser and then print it.
 Adobe Acrobat PDF
 Microsoft Word

You can print directly from your browser using the link below. The printout will probably go onto a second page.
 Print Version (Web)

Monthly E-mail Updates

The InfoNet updates its Fact Sheets frequently. A listing of each month's changes is posted to several e-mail lists.

If you would like to receive this monthly update by personal e-mail, please click on the SUBMIT button.

SUBMIT